Neuroscience
Neuroscience · ScienceFebruary 20265 min read

The brain that rewires itself

For much of the last century, the adult brain was thought to be fixed. We now know it is quietly remodelling itself, all the time.

By the Arc editorial team

For much of the last century, the adult brain was thought to be fixed. We now know it is quietly remodelling itself, all the time.

One of the great reversals in modern neuroscience is this: the adult brain is not the finished, unchangeable organ it was long assumed to be. It is plastic, constantly reshaping itself in response to what we do.

What plasticity means

Neuroplasticity is the brain's ability to reorganise itself by forming new synaptic connections throughout life.1 It is not one process but many: the strengthening and weakening of synapses, the growth and retraction of connections, the sprouting of axons and dendrites, and even, in specific regions, the birth of entirely new neurons.1

The brain is less a finished sculpture than a landscape, endlessly reworked by use.

New neurons, even in adulthood

Perhaps the most surprising piece is adult neurogenesis, the generation of new neurons in parts of the brain including the hippocampus, where they contribute to learning, memory, and repair.2 The brain, it turns out, retains a capacity for renewal well beyond childhood.

Why it matters, and where it leads

Plasticity is why we can still learn a language at forty, and it is central to how the brain recovers after a stroke or injury, remodelling circuits around the damage.3 Understanding, and one day guiding, that capacity is among the most hopeful frontiers in neuroscience.

References

  1. Neuroplasticity. StatPearls, NCBI Bookshelf. ncbi.nlm.nih.gov
  2. Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement. PMC. ncbi.nlm.nih.gov
  3. Neuroplasticity and Nervous System Recovery: Cellular Mechanisms, Therapeutic Advances, and Future Prospects. PMC. ncbi.nlm.nih.gov
More from Neuroscience All insights

Keep exploring

On the arc of human discovery.